Button misalignment is a common issue in web development that can negatively impact user experience and interface professionalism. The most effective prevention methods include using CSS Flexbox for one-dimensional layouts, which provides excellent alignment control through properties like justify-content and align-items. CSS Grid offers superior two-dimensional layout capabilities, allowing precise button placement through grid template areas. Implementing responsive design principles ensures buttons maintain proper alignment across different screen sizes, while consistent margin and padding values create reliable spacing. Modern front-end frameworks like Bootstrap include built-in alignment systems that automatically handle button positioning. Developers should also avoid mixing different positioning methods, use CSS reset files to eliminate browser inconsistencies, and conduct cross-browser testing to identify alignment issues. Proper HTML semantic structure with appropriate container elements provides the foundation for stable button placement. Additionally, using relative units like percentages or ems instead of fixed pixels helps maintain alignment during zoom operations and across various display densities. Regular code validation and adherence to web standards further prevent unexpected alignment problems that can frustrate users and diminish interface quality.