Arcade cabinets are designed with distinct approaches for sit-down and stand-up gameplay experiences, focusing on player comfort, space efficiency, and gameplay requirements. Stand-up arcade cabinets typically feature vertical orientations with control panels positioned at waist height, allowing players to maintain an upright posture while accessing controls comfortably. These cabinets prioritize space efficiency in crowded arcades and often include footrails for leaning during extended play sessions. The monitor angle is usually tilted slightly upward to accommodate the standing player's sightlines.

In contrast, sit-down arcade cabinets are designed with lower profiles and integrated seating, either as enclosed cockpits or open bench-style units. These designs position controls at lap level with monitors placed closer to eye level when seated. Cockpit-style cabinets often feature wraparound displays and enhanced audio systems that create immersive environments for racing games and flight simulators. The seating arrangement allows for longer gameplay sessions without physical fatigue, making them ideal for extended play.

Control panel layouts also differ significantly between the two designs. Stand-up cabinets typically feature simpler, more accessible control schemes with joysticks and buttons arranged for immediate accessibility. Sit-down versions often incorporate more complex setups including steering wheels, flight sticks, or specialized controllers that require the stability of seated operation. Cabinet dimensions vary accordingly, with stand-up units being taller but having smaller footprints, while sit-down models require more floor space but provide dedicated seating areas. Both designs consider coin operation mechanisms and maintenance access points, though their placement varies based on the cabinet's overall structure and intended usage environment.