Designing arcade machines for healthcare environments presents unique engineering and design hurdles that differ significantly from commercial entertainment applications. The primary challenge involves infection control and sanitization, requiring non-porous, medical-grade materials that can withstand harsh disinfectants while maintaining functionality. Accessibility becomes paramount, necessitating adaptable interfaces for patients with limited mobility, visual impairments, or cognitive differences. Regulatory compliance with medical device standards adds another layer of complexity, requiring rigorous documentation and safety certifications. Durability requirements exceed typical arcade standards, as machines must withstand constant use in clinical environments while maintaining precision calibration for therapeutic applications. Furthermore, therapeutic efficacy must be scientifically validated, requiring collaboration between game designers and healthcare professionals to ensure activities deliver measurable clinical benefits. The integration of progress tracking and data collection features must also comply with patient privacy regulations like HIPAA, creating additional technical constraints. These multifaceted challenges require interdisciplinary approaches combining medical expertise, rehabilitation science, and entertainment technology to create effective therapeutic arcade solutions.