Designing arcade machines for healthcare or therapy presents unique challenges that blend entertainment with medical efficacy. One major hurdle is regulatory compliance, as these devices must meet strict healthcare standards to ensure safety and effectiveness. Another challenge is balancing engagement and therapeutic value—games must be fun while also achieving clinical goals. Accessibility is critical, requiring designs that accommodate diverse physical and cognitive abilities. Additionally, data privacy and security must be prioritized to protect sensitive patient information. Finally, cost and scalability can be barriers, as high-quality therapeutic gaming solutions often require significant investment. Addressing these challenges is key to creating effective and enjoyable healthcare arcade experiences.