Designing arcade machines for universal accessibility presents several challenges that developers must address to ensure inclusivity. One major hurdle is creating intuitive and adaptable control systems that cater to players with varying physical abilities, such as those with limited mobility or visual impairments. Another challenge is ensuring the machine's physical design accommodates wheelchair users, requiring careful consideration of height, reach, and space.

Additionally, developers must integrate features like audio cues, high-contrast visuals, and customizable difficulty levels to support players with sensory or cognitive disabilities. The cost of implementing these accessibility features can also be prohibitive, making it difficult for smaller arcade operators to adopt them.

Finally, balancing accessibility with the traditional arcade experience is crucial, as overly complex adaptations might alienate mainstream players. Despite these challenges, prioritizing universal design in arcade machines can create a more inclusive gaming environment for all.